Thalamic volume, resting-state activity, and their association with the efficacy of electroconvulsive therapy

Akihiro Takamiya, Taishiro Kishimoto, Kuo ching Liang, Yuri Terasawa, S. Nishikata, Ryosuke Tarumi, Kyosuke Sawada, Shunya Kurokawa, Jinichi Hirano, Bun Yamagata, Masaru Mimura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Electroconvulsive therapy (ECT) is the most effective antidepressant treatment. Biological predictors of clinical outcome to ECT are valuable. We aimed to examine multimodal magnetic resonance imaging (MRI) data that correlates to the efficacy of ECT. Structural and resting-state functional MRI data were acquired from 46 individuals (25 depressed individuals who received ECT, and 21 healthy controls). Whole-brain grey matter volume (GMV) and fractional amplitude of low frequency fluctuations (fALFF) were investigated to identify brain regions associated with post-ECT Hamilton Depression Rating Scale (HAM-D) total scores. GMV and fALFF values were compared with those in healthy controls using analysis of covariance (ANCOVA). Remission was defined by HAM-D ≤7. A multiple regression analysis revealed that pretreatment smaller GMV in the left thalamus was associated with worse response to ECT (i.e. higher post-ECT HAM-D). Pretreatment higher fALFF in the right anterior insula, and lower fALFF in the left thalamus and the cerebellum were associated with worse outcomes. The left thalamus was identified in both GMV and fALFF analyses. Nonremitters showed significantly smaller thalamic GMV compared to remitters and controls. We found that pretreatment thalamic volume and resting-state activity were associated with the efficacy of ECT. Our results highlight the importance of the thalamus as a possible biological predictor and its role in the underlying mechanisms of ECT action.

本文言語English
ページ(範囲)135-141
ページ数7
ジャーナルJournal of Psychiatric Research
117
DOI
出版ステータスPublished - 2019 10月

ASJC Scopus subject areas

  • 精神医学および精神衛生
  • 生物学的精神医学

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