The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system

Tsutomu Takeuchi, Stuart F. Schlossman, Chikao Morimoto

研究成果: Article査読

24 被引用数 (Scopus)

抄録

It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.

本文言語English
ページ(範囲)107-114
ページ数8
ジャーナルCellular Immunology
107
1
DOI
出版ステータスPublished - 1987 6
外部発表はい

ASJC Scopus subject areas

  • 免疫学

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