The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome

Keisuke Kosumi, Tsuyoshi Hamada, Hideo Koh, Jennifer Borowsky, Susan Bullman, Tyler S. Twombly, Daniel Nevo, Yohei Masugi, Li Liu, Annacarolina da Silva, Yang Chen, Chunxia Du, Mancang Gu, Chenxi Li, Wanwan Li, Hongli Liu, Yan Shi, Kosuke Mima, Mingyang Song, Katsuhiko NoshoJonathan A. Nowak, Reiko Nishihara, Hideo Baba, Xuehong Zhang, Kana Wu, Molin Wang, Curtis Huttenhower, Wendy S. Garrett, Matthew L. Meyerson, Jochen K. Lennerz, Marios Giannakis, Andrew T. Chan, Jeffrey A. Meyerhardt, Charles S. Fuchs, Shuji Ogino

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Evidence indicates a complex link between microbiota, tumor characteristics, and host immunity in the tumor microenvironment. In experimental studies, bifidobacteria appear to modulate intestinal epithelial cell differentiation. Accumulating evidence suggests that bifidobacteria may enhance the antitumor immunity and efficacy of immunotherapy. We hypothesized that the amount of bifidobacteria in colorectal carcinoma tissue might be associated with tumor differentiation and higher immune response to colorectal cancer. Using a molecular pathologic epidemiology database of 1313 rectal and colon cancers, we measured the amount of Bifidobacterium DNA in carcinoma tissue by a quantitative PCR assay. The multivariable regression model was used to adjust for potential confounders, including microsatellite instability status, CpG island methylator phenotype, long-interspersed nucleotide element-1 methylation, and KRAS, BRAF, and PIK3CA mutations. Intratumor bifidobacteria were detected in 393 cases (30%). The amount of bifidobacteria was associated with the extent of signet ring cells (P = 0.002). Compared with Bifidobacterium-negative cases, multivariable odd ratios for the extent of signet ring cells were 1.29 (95% CI, 0.74–2.24) for Bifidobacterium-low cases and 1.87 (95% CI, 1.16–3.02) for Bifidobacterium-high cases (Ptrend = 0.01). The association between intratumor bifidobacteria and signet ring cells suggests a possible role of bifidobacteria in determining distinct tumor characteristics or as an indicator of dysfunctional mucosal barrier in colorectal cancer.

本文言語English
ページ(範囲)2839-2852
ページ数14
ジャーナルAmerican Journal of Pathology
188
12
DOI
出版ステータスPublished - 2018 12月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学

フィンガープリント

「The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル