The analysis, roles and regulation of quiescence in hematopoietic stem cells

Ayako Nakamura-Ishizu, Hitoshi Takizawa, Toshio Suda

研究成果: Review article

82 引用 (Scopus)

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Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of efficient self-renewal and differentiation; some of these have been shown to exist in a dormant, or quiescent, cell cycle state. Such quiescence has been proposed as a fundamental property of hematopoietic stem cells (HSCs) in the adult bone marrow, acting to protect HSCs from functional exhaustion and cellular insults to enable lifelong hematopoietic cell production. Recent studies have demonstrated that HSC quiescence is regulated by a complex network of cell-intrinsic and -extrinsic factors. In addition, detailed single-cell analyses and novel imaging techniques have identified functional heterogeneity within quiescent HSC populations and have begun to delineate the topological organization of quiescent HSCs. Here, we review the current methods available to measure quiescence in HSCs and discuss the roles of HSC quiescence and the various mechanisms by which HSC quiescence is maintained.

元の言語English
ページ(範囲)4656-4666
ページ数11
ジャーナルDevelopment (Cambridge)
141
発行部数24
DOI
出版物ステータスPublished - 2014 12 15
外部発表Yes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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