The antiaging approach for the treatment of dry eye

Kazuo Tsubota, Motoko Kawashima, Takaaki Inaba, Murat Dogru, Yukihiro Matsumoto, Reiko Ishida, Minako Kaido, Takashi Kojima, Miki Uchino, Yuichi Uchino, Yoko Ogawa, Shigeru Nakamura, Akihiro Higuchi, Ken Shinmura, Mitsuhiro Watanabe, Tetsuya Kawakita

研究成果: Article査読

27 被引用数 (Scopus)

抄録

ABSTRACT:: Dry eye is one of the most common eye disorders affecting millions of people. It causes ocular irritation or discomfort, and decreases functional vision, causing a dramatic deterioration in the quality of life. Although new treatments such as the P2Y2 agonist or cyclosporine eye drops have been developed and a certain level of patient satisfaction can now be obtained, no fundamental treatment has been developed. Currently, there is no therapy available to recover lacrimal function to its normal status. Recent progress in the understanding of aging has laid the foundations for a new way of thinking about intervention of the aging process. Because dry eye is accelerated by aging, a useful approach for the prevention or treatment of dry eye may be to interfere with the aging process. In the scientific community, there is a global consensus that calorie restriction can extend the life span of various kinds of animals, establishing an intervention to aging. Another important hypothesis believed to be involved in aging is the free radical theory. According to these theories, the aging process may be managed by controlling levels of calories or reactive oxygen species. In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye.

本文言語English
ページ(範囲)S3-S8
ジャーナルCornea
31
11 SUPPL.1
DOI
出版ステータスPublished - 2012 11

ASJC Scopus subject areas

  • 眼科学

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