The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells

Hideaki Naoe, Tatsuyuki Chiyoda, Jo Ishizawa, Kenta Masuda, Hideyuki Saya, Shinji Kuninaka

研究成果: Article

6 引用 (Scopus)

抜粋

Differentiation of placental trophoblast stem (TS) cells to trophoblast giant (TG) cells is accompanied by transition from a mitotic cell cycle to an endocycle. Here, we report that Cdh1, a regulator of the anaphase-promoting complex/cyclosome (APC/C), negatively regulates mitotic entry upon the mitotic/endocycle transition. TS cells derived from homozygous Cdh1 gene-trapped (Cdh1GT/GT) murine embryos accumulated mitotic cyclins and precociously entered mitosis after induction of TS cell differentiation, indicating that Cdh1 is required for the switch from mitosis to the endocycle. Furthermore, the Cdh1GT/GT TS cells and placenta showed aberrant expression of placental differentiation markers. These data highlight an important role of Cdh1 in the G2/M transition during placental differentiation.

元の言語English
ページ(範囲)757-762
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
430
発行部数2
DOI
出版物ステータスPublished - 2013 1 11

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用