The bridge treatment selected at the decision for transplantation did not affect the outcomes in patients with MDS

Shinichi Kako, Yoshinobu Kanda, Jun Kato, Wataru Yamamoto, Seiko Kato, Makoto Onizuka, Akira Yokota, Raine Tatara, Hiroki Yokoyama, Maki Hagihara, Kensuke Usuki, Moritaka Gotoh, Reiko Watanabe, Nobutaka Kawai, Takayuki Saitoh, Heiwa Kanamori, Satoshi Takahashi, Shinichiro Okamoto

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The optimal treatment for use as a bridge to allogeneic hematopoietic stem cell transplantation at the decision for transplantation has not been established in patients with myelodysplastic syndrome (MDS). We retrospectively evaluated the clinical outcomes after the decision for transplantation in our patients with MDS or acute myeloid leukemia (AML) secondary to MDS, aged more than 15 years, who underwent transplantation between 2007 and 2012. A total of 124 patients were included. We classified patients into two groups according to the bridge treatment selected at the decision for transplantation: Group 1, supportive care (n = 79), immunosuppressive therapy (n = 7), low-dose chemotherapy (n = 12); Group 2, AML-type induction chemotherapy (ICT: n = 22), azacitidine (Aza: n = 4). The rate of blasts in the bone marrow significantly influenced the treatment selection at the time of decision. There was no significant difference between the two groups in the rate of overall survival (OS) from the decision (73.1% vs 80.4% at 1 year) or from transplantation (59.0% vs 59.2% at 1 year). A significant difference was not observed even after patients were stratified according to either the rate of blasts in the bone marrow at the time of decision or the propensity score. In conclusion, the bridge treatment selected at the decision for transplantation did not affect the outcomes of transplantation in patients with MDS. However, this analysis did not include patients who could not undergo transplantation after the decision, and thus a prospective study is warranted.

本文言語English
ページ(範囲)341-349
ページ数9
ジャーナルHematological Oncology
35
3
DOI
出版ステータスPublished - 2017 9

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

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