The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age

Takeshi Arimitsu, Yasuyo Minagawa, Tatsuhiko Yagihashi, Mariko O. Uchida, Atsuko Matsuzaki, Kazushige Ikeda, Takao Takahashi

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Higher brain dysfunction, such as language delay, is a major concern among preterm infants. Cerebral substrates of cognitive development in preterm infants remain elusive, partly because of limited methods. The present study focuses on hemodynamic response patterns for brain function by using near-infrared spectroscopy. Specifically, the study investigates gestational differences in the hemodynamic response pattern evoked in response to phonetic changes of speech and cerebral hemispheric specialization of the auditory area in preterm infants (n = 60) and term infants (n = 20). Eighty neonates born between 26 and 41 weeks of gestational age (GA) were tested from 33 to 41 weeks of postmenstrual age (PMA). We analyzed the hemodynamic response pattern to phonemic and prosodic contrasts for multiple channels on temporal regions and the laterality index of the auditory area. Preterm infants younger than 39 weeks of PMA showed significantly atypical hemodynamic patterns, with an inverted response shape. Partial correlation analysis of the typicality score of hemodynamic response revealed a significant positive correlation with PMA. The laterality index of preterm infants from 39 weeks of PMA demonstrated a tendency rightward dominance for prosodic changes similar to term infants. We provide new evidence that alterations in hemodynamic regulation and the functional system for phonemic and prosodic processing in preterm infants catch up by their projected due dates.

本文言語English
ページ(範囲)599-606
ページ数8
ジャーナルNeuroImage: Clinical
19
DOI
出版ステータスPublished - 2018 1月 1

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング
  • 神経学
  • 臨床神経学
  • 認知神経科学

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