The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: An analysis of 147 cases

Yukihiro Nakanishi, Atsushi Ochiai, Kimio Yoshimura, Hoichi Kato, Tadakazu Shimoda, Hajime Yamaguchi, Yuji Tachimori, Hiroshi Watanabe, Setsuo Hirohashi

研究成果: Article

26 引用 (Scopus)

抄録

BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.

元の言語English
ページ(範囲)1454-1459
ページ数6
ジャーナルCancer
82
発行部数8
DOI
出版物ステータスPublished - 1998 4 15
外部発表Yes

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Mucous Membrane
Carcinoma
Neoplasms
Incidence
Tobacco Use
Alcohol Drinking
Alcohols
Lugol's solution
Staining and Labeling
Light

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma : An analysis of 147 cases. / Nakanishi, Yukihiro; Ochiai, Atsushi; Yoshimura, Kimio; Kato, Hoichi; Shimoda, Tadakazu; Yamaguchi, Hajime; Tachimori, Yuji; Watanabe, Hiroshi; Hirohashi, Setsuo.

:: Cancer, 巻 82, 番号 8, 15.04.1998, p. 1454-1459.

研究成果: Article

Nakanishi, Yukihiro ; Ochiai, Atsushi ; Yoshimura, Kimio ; Kato, Hoichi ; Shimoda, Tadakazu ; Yamaguchi, Hajime ; Tachimori, Yuji ; Watanabe, Hiroshi ; Hirohashi, Setsuo. / The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma : An analysis of 147 cases. :: Cancer. 1998 ; 巻 82, 番号 8. pp. 1454-1459.
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abstract = "BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12{\%}) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35{\%}) had 6-10 and 78 (53{\%}) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.",
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T1 - The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma

T2 - An analysis of 147 cases

AU - Nakanishi, Yukihiro

AU - Ochiai, Atsushi

AU - Yoshimura, Kimio

AU - Kato, Hoichi

AU - Shimoda, Tadakazu

AU - Yamaguchi, Hajime

AU - Tachimori, Yuji

AU - Watanabe, Hiroshi

AU - Hirohashi, Setsuo

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N2 - BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.

AB - BACKGROUND. Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS. For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS. Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS. Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.

KW - Alcohol

KW - Dysplasia

KW - Esophageal carcinoma

KW - Head and neck cancer

KW - Lugol's iodine-unstained area

KW - Multicentricity

KW - Tobacco

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