The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Hitoshi Nakashima, Hisako Inoue, Mitsuteru Akahoshi, Yosuke Tanaka, Kunihiro Yamaoka, Eiichi Ogami, Shuuji Nagano, Yojiro Arinobu, Hiroaki Niiro, Takeshi Otsuka, Yoshiyuki Niho

研究成果: Article

53 引用 (Scopus)

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Genetic factors seem to play a significant role in susceptibility to systemic lupus erythematosus (SLE). We previously described the amino acid polymorphism (Val14Met) within the IFN-γ receptor 1 (IFN-γR1), and that the frequency of the Met14 allele in SLE patients was significantly higher than that of the healthy control population. We also found an amino acid polymorphism (Gln64Arg) within IFN-γ receptor 2 (IFN-γR2). Since the IFN-γ receptor is a complex consisting of IFN-γR1 and IFN-γR2, we searched for the particular combination of two kinds of amino acid polymorphisms found within the IFN-γ receptor which plays a prominent role in susceptibility to SLE. The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype.

元の言語English
ページ(範囲)187-190
ページ数4
ジャーナルFEBS Letters
453
発行部数1-2
DOI
出版物ステータスPublished - 1999 6 18

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Nakashima, H., Inoue, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T., & Niho, Y. (1999). The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus. FEBS Letters, 453(1-2), 187-190. https://doi.org/10.1016/S0014-5793(99)00701-2