The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development

Makoto Hosoya, Masato Fujioka, Ayako Y. Murayama, Hideyuki Okano, Kaoru Ogawa

研究成果: Article査読

抄録

Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate-specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.

本文言語English
ページ(範囲)325-353
ページ数29
ジャーナルFEBS Journal
288
1
DOI
出版ステータスPublished - 2021 1

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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