The Design of Membrane-Controlled Transdermal Therapeutic Systems Containing Molsidomine

Masayuki Yamada, Yusuke Tanigawara

研究成果: Article査読

3 被引用数 (Scopus)

抄録

A basic investigation aimed at developing a membrane-controlled transdermal therapeutic system was carried out. The drug used was molsidomine with oleic acid and propylene glycol as the absorption enhancer and the vehicle, respectively. It was concluded that a microporous polyethylene membrane was most suitable for release control. A desirable pattern of the molsidomine plasma concentration versus time curve could be obtained by controlling the amounts of the three components, molsidomine, oleic acid, and propylene glycol in the device. Furthermore, the plasma concentration of molsidomine was well sustained by adding polyethyleneglycol 400 to the oleic acid-propylene glycol solution.

本文言語English
ページ(範囲)3407-3412
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
35
8
DOI
出版ステータスPublished - 1987 1月 1
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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