The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49

Tomoko Takamiya, Takashi Kadowaki, Wahid R. Zaky, Hirotsugu Ueshima, Rhobert W. Evans, Tomonori Okamura, Atsunori Kashiwagi, Yasuyuki Nakamura, Yoshiyuki Kita, Russell P. Tracy, Lewis H. Kuller, Akira Sekikawa

研究成果: Article

5 引用 (Scopus)

抄録

Background: Elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels were associated with higher incidence of type II diabetes. Elucidating the determinants of PAI-1 in various ethnicities may help to understand the susceptibility to developing diabetes. The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels. Methods: We conducted a cross-sectional study on a total of 198 men aged 40-49 in the US (Body mass index (BMI): 27.0 ± 3.3 kg/m2) and Japan (BMI: 23.3 ± 3.1 kg/m2). Examination included physique measurement (BMI and waist girth), blood analysis (lipid profiles, glucose, insulin, C-reactive protein, and PAI-1), and life-style assessment by self-administered questionnaires. Results: PAI-1 levels were significantly lower in American than in Japanese men, even after adjustment for age, waist girth, cigarette smoking, habitual alcohol drinking, and other factors. In the Americans, waist girth, insulin, and cigarette smoking were significantly associated with PAI-1 levels, while waist girth and triglycerides were significantly associated with PAI-1 levels in the Japanese. Conclusions: PAI-1 levels were significantly lower in American than in Japanese men and the determinants of PAI-1 levels differ for American and Japanese men aged 40-49.

元の言語English
ページ(範囲)176-182
ページ数7
ジャーナルDiabetes Research and Clinical Practice
72
発行部数2
DOI
出版物ステータスPublished - 2006 5
外部発表Yes

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Plasminogen Activator Inhibitor 1
Body Mass Index
Smoking
Insulin
Alcohol Drinking
C-Reactive Protein
Type 2 Diabetes Mellitus
Life Style
Japan
Triglycerides
Cross-Sectional Studies
Lipids
Glucose

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

これを引用

The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49. / Takamiya, Tomoko; Kadowaki, Takashi; Zaky, Wahid R.; Ueshima, Hirotsugu; Evans, Rhobert W.; Okamura, Tomonori; Kashiwagi, Atsunori; Nakamura, Yasuyuki; Kita, Yoshiyuki; Tracy, Russell P.; Kuller, Lewis H.; Sekikawa, Akira.

:: Diabetes Research and Clinical Practice, 巻 72, 番号 2, 05.2006, p. 176-182.

研究成果: Article

Takamiya, T, Kadowaki, T, Zaky, WR, Ueshima, H, Evans, RW, Okamura, T, Kashiwagi, A, Nakamura, Y, Kita, Y, Tracy, RP, Kuller, LH & Sekikawa, A 2006, 'The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49', Diabetes Research and Clinical Practice, 巻. 72, 番号 2, pp. 176-182. https://doi.org/10.1016/j.diabres.2005.10.015
Takamiya, Tomoko ; Kadowaki, Takashi ; Zaky, Wahid R. ; Ueshima, Hirotsugu ; Evans, Rhobert W. ; Okamura, Tomonori ; Kashiwagi, Atsunori ; Nakamura, Yasuyuki ; Kita, Yoshiyuki ; Tracy, Russell P. ; Kuller, Lewis H. ; Sekikawa, Akira. / The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49. :: Diabetes Research and Clinical Practice. 2006 ; 巻 72, 番号 2. pp. 176-182.
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abstract = "Background: Elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels were associated with higher incidence of type II diabetes. Elucidating the determinants of PAI-1 in various ethnicities may help to understand the susceptibility to developing diabetes. The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels. Methods: We conducted a cross-sectional study on a total of 198 men aged 40-49 in the US (Body mass index (BMI): 27.0 ± 3.3 kg/m2) and Japan (BMI: 23.3 ± 3.1 kg/m2). Examination included physique measurement (BMI and waist girth), blood analysis (lipid profiles, glucose, insulin, C-reactive protein, and PAI-1), and life-style assessment by self-administered questionnaires. Results: PAI-1 levels were significantly lower in American than in Japanese men, even after adjustment for age, waist girth, cigarette smoking, habitual alcohol drinking, and other factors. In the Americans, waist girth, insulin, and cigarette smoking were significantly associated with PAI-1 levels, while waist girth and triglycerides were significantly associated with PAI-1 levels in the Japanese. Conclusions: PAI-1 levels were significantly lower in American than in Japanese men and the determinants of PAI-1 levels differ for American and Japanese men aged 40-49.",
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author = "Tomoko Takamiya and Takashi Kadowaki and Zaky, {Wahid R.} and Hirotsugu Ueshima and Evans, {Rhobert W.} and Tomonori Okamura and Atsunori Kashiwagi and Yasuyuki Nakamura and Yoshiyuki Kita and Tracy, {Russell P.} and Kuller, {Lewis H.} and Akira Sekikawa",
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T1 - The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49

AU - Takamiya, Tomoko

AU - Kadowaki, Takashi

AU - Zaky, Wahid R.

AU - Ueshima, Hirotsugu

AU - Evans, Rhobert W.

AU - Okamura, Tomonori

AU - Kashiwagi, Atsunori

AU - Nakamura, Yasuyuki

AU - Kita, Yoshiyuki

AU - Tracy, Russell P.

AU - Kuller, Lewis H.

AU - Sekikawa, Akira

PY - 2006/5

Y1 - 2006/5

N2 - Background: Elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels were associated with higher incidence of type II diabetes. Elucidating the determinants of PAI-1 in various ethnicities may help to understand the susceptibility to developing diabetes. The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels. Methods: We conducted a cross-sectional study on a total of 198 men aged 40-49 in the US (Body mass index (BMI): 27.0 ± 3.3 kg/m2) and Japan (BMI: 23.3 ± 3.1 kg/m2). Examination included physique measurement (BMI and waist girth), blood analysis (lipid profiles, glucose, insulin, C-reactive protein, and PAI-1), and life-style assessment by self-administered questionnaires. Results: PAI-1 levels were significantly lower in American than in Japanese men, even after adjustment for age, waist girth, cigarette smoking, habitual alcohol drinking, and other factors. In the Americans, waist girth, insulin, and cigarette smoking were significantly associated with PAI-1 levels, while waist girth and triglycerides were significantly associated with PAI-1 levels in the Japanese. Conclusions: PAI-1 levels were significantly lower in American than in Japanese men and the determinants of PAI-1 levels differ for American and Japanese men aged 40-49.

AB - Background: Elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels were associated with higher incidence of type II diabetes. Elucidating the determinants of PAI-1 in various ethnicities may help to understand the susceptibility to developing diabetes. The aim of our study was to compare PAI-1 levels between Americans and the Japanese in the post-war generation and to elucidate the determinants of the PAI-1 levels. Methods: We conducted a cross-sectional study on a total of 198 men aged 40-49 in the US (Body mass index (BMI): 27.0 ± 3.3 kg/m2) and Japan (BMI: 23.3 ± 3.1 kg/m2). Examination included physique measurement (BMI and waist girth), blood analysis (lipid profiles, glucose, insulin, C-reactive protein, and PAI-1), and life-style assessment by self-administered questionnaires. Results: PAI-1 levels were significantly lower in American than in Japanese men, even after adjustment for age, waist girth, cigarette smoking, habitual alcohol drinking, and other factors. In the Americans, waist girth, insulin, and cigarette smoking were significantly associated with PAI-1 levels, while waist girth and triglycerides were significantly associated with PAI-1 levels in the Japanese. Conclusions: PAI-1 levels were significantly lower in American than in Japanese men and the determinants of PAI-1 levels differ for American and Japanese men aged 40-49.

KW - Epidemiology

KW - Japan

KW - PAI-1

KW - Post-war generation

KW - US

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