The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands

Yasumasa Sasaki, Kazuo Tsubota, Jitesh D. Kawedia, Anil G. Menon, Masato Yasui

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Purpose: This study was designed to clarify the physiological function and tissue distribution of aquaporin 5 (AQP5) in the lacrimal and parotid glands. Methods: Saliva and tear volumes were compared in AQP5 knockout (AQP5-/-) mice and wild-type mice. Immunohistochemistry and immunoblot analysis were performed in wild-type and AQP5-/- mice. Results: Immunofluorescence of AQP5 staining showed that AQP5 was localized mainly in the ductal cells rather than in the acinar cells of the lacrimal gland. In contrast, in the parotid gland, AQP5 was observed abundantly in acinar cells with undetectable staining in ductal cells. Tear secretion was not changed in AQP5-/- mouse, although saliva secretion was significantly reduced. Conclusions: AQP5 distribution in acinar cells and ductal cells was completely opposite in the lacrimal and parotid glands. The physiological role of AQP5 might be dependent on the characteristic tissue distribution of the protein in the lacrimal and parotid glands.

本文言語English
ページ(範囲)923-929
ページ数7
ジャーナルCurrent Eye Research
32
11
DOI
出版ステータスPublished - 2007 11月

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

フィンガープリント

「The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル