The effect of testosterone upon the urate reabsorptive transport system in mouse kidney

M. Hosoyamada, Y. Takiue, T. Shibasaki, H. Saito

研究成果: Article査読

28 被引用数 (Scopus)

抄録

It is hypothesized that hyperuricemia in males is caused by androgen-induced urate reabsorptive transport system in the kidney. The expression of urate transporter 1 (Urat1), sodium-coupled monocarboxylate transporter 1 (Smct1) and glucose transporter 9 (Glut9) were investigated in orchiectomized mice with or without testosterone replacement. Testosterone enhanced mRNA and protein levels of Smct1 while those of Glut9 were attenuated. Although the mRNA level of Urat1 was enhanced by testosterone, the corresponding levels of Urat1 protein remained unaffected. Thus, the induction of Smct1 by testosterone is a candidate mechanism underlying hyperuricemia in males.

本文言語English
ページ(範囲)574-579
ページ数6
ジャーナルNucleosides, Nucleotides and Nucleic Acids
29
7
DOI
出版ステータスPublished - 2010 7月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 遺伝学

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