The effect of the microstructure of β-tricalcium phosphate on the metabolism of subsequently formed bone tissue

Takatoshi Okuda, Koji Ioku, Ikuho Yonezawa, Hideyuki Minagi, Giichiro Kawachi, Yoshinori Gonda, Hisashi Murayama, Yasuaki Shibata, Soichiro Minami, Shimeru Kamihira, Hisashi Kurosawa, Tohru Ikeda

研究成果: Article査読

130 被引用数 (Scopus)

抄録

The response of bone cells to a newly developed porous β-tricalcium phosphate composed of rod-shaped particles (RSβ-TCP), β-TCP composed of conventional non-rod-shaped particles (Cβ-TCP), and hydroxyapatite (HA) was analyzed using in vivo implantation and in vitro osteoclastogenesis systems. Implantation of the materials into the rabbit femur showed that RSβ-TCP and Cβ-TCP were bioresorbable, but HA was not. Up to 12 weeks after the implantation, bioresorption of RSβ-TCP and Cβ-TCP accompanied by the formation of new bone occurred satisfactorily. At 24 weeks post-implantation, most of the RSβ-TCP had been absorbed, and active osteogenesis was preserved in the region. However, in the specimens implanted with Cβ-TCP, the amount of not only the implanted Cβ-TCP but also the newly formed bone tissue decreased, and bone marrow dominated the region. The implanted HA was unbioresorbable throughout the experimental period. When osteoclasts were generated on RSβ-TCP, Cβ-TCP, or HA disks, apparent resorption lacunae were formed on the RSβ-TCP and Cβ-TCP, but not HA disks. Quantitation of the calcium concentration in the culture media showed an earlier and more constant release of calcium from RSβ-TCP than Cβ-TCP. These results showed that the microstructure of β-TCP affects the activity of bone cells and subsequent bone replacement.

本文言語English
ページ(範囲)2612-2621
ページ数10
ジャーナルBiomaterials
28
16
DOI
出版ステータスPublished - 2007 6月
外部発表はい

ASJC Scopus subject areas

  • バイオエンジニアリング
  • セラミックおよび複合材料
  • 生物理学
  • 生体材料
  • 材料力学

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