The effect of VIP/PACAP family of peptides on pancreatic blood flow and secretion in conscious dogs

Osamu Ito, Satoru Naruse, Motoji Kitagawa, Hiroshi Ishiguro, Shigeru Ko, Morio Nakajima, Tetsuo Hayakawa

研究成果: Article査読

15 被引用数 (Scopus)


The effects of PACAP-38, PACAP-27, VIP and secretin on pancreatic blood flow were compared with those of meals in five conscious dogs using an ultrasound transit-time blood flow meter. All peptides (1-100 pmol/kg) induced dose-related increases of pancreatic blood flow, and fluid and bicarbonate secretion. Only PACAPs stimulated protein secretion. Both PACAPs at doses which did not stimulate pancreatic secretion, induced significant pancreatic vasodilatation. VIP was less potent than PACAP-38 and PACAP-27 at lower doses (1-25 pmol/kg), but was similar to PACAPs at higher doses. The maximal effects of PACAPs and VIP were comparable to those observed after meals. Secretin was a significant but weak vasodilator. When pancreatic secretion was maximally stimulated by secretin, a reduction of vascular resistance was 75% of postprandial peak levels. PACAP(6-38), a competitive antagonist of PACAP, inhibited pancreatic vascular responses to PACAPs, but not those to VIP and secretin. Its inhibitory effects on protein response to PACAPs were not significant. Atropine inhibited pancreatic protein but not the vascular effect of PACAP-27. Pancreatic vasodilatation by PACAPs appears to be mediated by both PACAP-specific and VIP/PACAP common receptors in dogs. PACAP, like VIP, is a good candidate for a mediator of atropine-resistant vasodilatation of the pancreas. Copyright (C) 1998 Elsevier Science B.V.

ジャーナルRegulatory Peptides
出版ステータスPublished - 1998 11 30

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 内分泌学
  • 臨床生化学
  • 細胞および分子神経科学


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