The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Fernando Caravaggio, Shunichiro Shinagawa, Yusuke Iwata, Philip Gerretsen, Julia Kim, Hiroyoshi Takeuchi, Raihaan Patel, M. Mallar Chakravarty, Antonio Strafella, Ariel Graff-Guerrero

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAPHIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAPHIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAPHIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.

本文言語English
ページ(範囲)341-347
ページ数7
ジャーナルJournal of Alzheimer's Disease
60
2
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 神経科学(全般)
  • 臨床心理学
  • 老年医学
  • 精神医学および精神衛生

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