The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Takashi Kanaya, Koji Hase, Daisuke Takahashi, Shinji Fukuda, Katsuaki Hoshino, Izumi Sasaki, Hiroaki Hemmi, Kathryn A. Knoop, Nachiket Kumar, Mayuko Sato, Tatsuro Katsuno, Osamu Yokosuka, Kiminori Toyooka, Kumiko Nakai, Ayako Sakamoto, Yuuki Kitahara, Toshi Jinnohara, Stephen J. Mcsorley, Tsuneyasu Kaisho, Ifor R. WilliamsHiroshi Ohno

研究成果: Article査読

143 被引用数 (Scopus)

抄録

Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous administration of the cytokine RANKL can synchronously activate M-cell differentiation in mice. Here we show the Ets transcription factor Spi-B was induced early during M-cell differentiation. Absence of Spi-B silenced the expression of various M-cell markers and prevented the differentiation of M cells in mice. The activation of T cells via an oral route was substantially impaired in the intestine of Spi-B-deficient (Spib -/-) mice. Our study demonstrates that commitment to the intestinal M-cell lineage requires Spi-B as a candidate master regulator.

本文言語English
ページ(範囲)729-736
ページ数8
ジャーナルNature Immunology
13
8
DOI
出版ステータスPublished - 2012 8月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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