The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice

Akira Moriguchi, Kazuhiro Ikenaka, Teiichi Furuichi, Hideyuki Okano, Yasuno Iwasaki, Katsuhiko Mikoshiba

研究成果: Article

22 引用 (Scopus)

抄録

The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.

元の言語English
ページ(範囲)333-337
ページ数5
ジャーナルGene
55
発行部数2-3
DOI
出版物ステータスPublished - 1987
外部発表Yes

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Jimpy Mice
Myelin Proteolipid Protein
Proteolipids
Exons
Brain
Genes
Messenger RNA
Proteins
Ribonucleases
Mutation

ASJC Scopus subject areas

  • Genetics

これを引用

The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. / Moriguchi, Akira; Ikenaka, Kazuhiro; Furuichi, Teiichi; Okano, Hideyuki; Iwasaki, Yasuno; Mikoshiba, Katsuhiko.

:: Gene, 巻 55, 番号 2-3, 1987, p. 333-337.

研究成果: Article

Moriguchi, Akira ; Ikenaka, Kazuhiro ; Furuichi, Teiichi ; Okano, Hideyuki ; Iwasaki, Yasuno ; Mikoshiba, Katsuhiko. / The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. :: Gene. 1987 ; 巻 55, 番号 2-3. pp. 333-337.
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AU - Okano, Hideyuki

AU - Iwasaki, Yasuno

AU - Mikoshiba, Katsuhiko

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KW - RNase A and T1 mapping

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