The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice

Akira Moriguchi, Kazuhiro Ikenaka, Teiichi Furuichi, Hideyuki Okano, Yasuno Iwasaki, Katsuhiko Mikoshiba

研究成果: Article査読

24 被引用数 (Scopus)

抄録

The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.

本文言語English
ページ(範囲)333-337
ページ数5
ジャーナルGene
55
2-3
DOI
出版ステータスPublished - 1987
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

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