The Fundamental and Clinical Studies on Cefpiramide in Pediatric Field

Keiji Jozaki, Satoshi Iwata, Yukio Iwasaki, Yoshitake Sato, Hatsuno Sano, Ryo Wakabayashi, Shinya Hayano, Masahiro Ihara, Kosuke Sunakawa, Mttsuru Osano

研究成果: Article

抜粋

Fundamental and clinical studies on cefpiramide (CPM), a new semisynthetic cephalosporin, were made and the following results were obtained. The antibacterial activities of CPM against clinical isolates were almost similar to those of conventional cephems except for Pseudomonas aeruginosa. The antibacterial activity of CPM against P, aeruginosa was excellent and superior than those of the others. Ten or twenty mg/kg of CPM was given intravenously at one shot to 11 cases. The mean serum levels of CPM reached 231 µg/ml at 15 minutes, 119µg/ml at 30 minutes, 88µg/ml at 1 hour, 65µg/ml at 2 hours and 33µg/ml at 6 hours after administration at a single dose of 10 mg/kg, respectively with the half-life of 3.42 hours. In case of 20 mg/kg, the mean serum levels attained 306 jug/ml at 15 minutes, 245µg/ml at 30 minutes, 160µg/ml at 1 hour, 118µg/ml at 2 hours and 66µg/ml at 6 hours respectively after administration with the half-life of 5.20 hours. CPM was given intravenously to 12 patients with various bacterial infections. The clinical effects were excellent in 5 cases, good in 6 cases and poor in 1 case and the effective rate was 92%. No side effect was observed in all cases.

元の言語English
ページ(範囲)2195-2200
ページ数6
ジャーナルthe japanese journal of antibiotics
36
発行部数8
DOI
出版物ステータスPublished - 1983 1 1

    フィンガープリント

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Jozaki, K., Iwata, S., Iwasaki, Y., Sato, Y., Sano, H., Wakabayashi, R., Hayano, S., Ihara, M., Sunakawa, K., & Osano, M. (1983). The Fundamental and Clinical Studies on Cefpiramide in Pediatric Field. the japanese journal of antibiotics, 36(8), 2195-2200. https://doi.org/10.11553/antibiotics1968b.36.2195