The GC skew index: A measure of genomic compositional asymmetry and the degree of replicational selection

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Circular bacterial chromosomes have highly polarized nucleotide composition in the two replichores, and this genomic strand asymmetry can be visualized using GC skew graphs. Here we propose and discuss the GC skew index (GCSI) for the quantifi cation of genomic compositional skew, which combines a normalized measure of fast Fourier transform to capture the shape of the skew graph and Euclidean distance between the two vertices in a cumulative skew graph to represent the degree of skew. We calculated GCSI for all available bacterial genomes, and GCSI correlated well with the visibility of GC skew. This novel index is useful for estimating confi dence levels for the prediction of replication origin and terminus by methods based on GC skew and for measuring the strength of replicational selection in a genome.

本文言語English
ページ(範囲)159-168
ページ数10
ジャーナルEvolutionary Bioinformatics
3
DOI
出版ステータスPublished - 2007 9 6

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 遺伝学
  • コンピュータ サイエンスの応用

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