The gene for multiple familial trichoepithelioma maps to chromosome 9p21

Hiroshi Harada, Ken Hashimoto, Minoru S.H. Ko

研究成果: Article査読

103 被引用数 (Scopus)

抄録

Multiple familial trichoepithelioma (MFT) is an autosomal dominant skin disease characterized by the presence of many small tumors predominantly on the face. To map the causative gene, we performed linkage analysis with microsatellite markers in three American families. We found a significant linkage of a gene for MFT to chromosome 9p21. The maximum combined lod score was 3.31 at D9S171 at θ = 0. The disease locus was defined to a 4-cM region between IFNA and D9S126. Because several tumor suppressor genes including p16 and p15 have been mapped to this region, the gene for MFT may also be a tumor suppressor.

本文言語English
ページ(範囲)41-43
ページ数3
ジャーナルJournal of Investigative Dermatology
107
1
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

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