抄録
Multiple familial trichoepithelioma (MFT) is an autosomal dominant skin disease characterized by the presence of many small tumors predominantly on the face. To map the causative gene, we performed linkage analysis with microsatellite markers in three American families. We found a significant linkage of a gene for MFT to chromosome 9p21. The maximum combined lod score was 3.31 at D9S171 at θ = 0. The disease locus was defined to a 4-cM region between IFNA and D9S126. Because several tumor suppressor genes including p16 and p15 have been mapped to this region, the gene for MFT may also be a tumor suppressor.
本文言語 | English |
---|---|
ページ(範囲) | 41-43 |
ページ数 | 3 |
ジャーナル | Journal of Investigative Dermatology |
巻 | 107 |
号 | 1 |
DOI | |
出版ステータス | Published - 1996 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 分子生物学
- 皮膚病学
- 細胞生物学