The gut microbiota and inflammatory bowel disease

Katsuyoshi Matsuoka, Takanori Kanai

研究成果: Review article査読

346 被引用数 (Scopus)

抄録

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically susceptible host. The advancement of next-generation sequencing technology has enabled identification of various alterations of the gut microbiota composition in IBD. While some results related to dysbiosis in IBD are different between studies owing to variations of sample type, method of investigation, patient profiles, and medication, the most consistent observation in IBD is reduced bacterial diversity, a decrease of Firmicutes, and an increase of Proteobacteria. It has not yet been established how dysbiosis contributes to intestinal inflammation. Many of the known IBD susceptibility genes are associated with recognition and processing of bacteria, which is consistent with a role of the gut microbiota in the pathogenesis of IBD. A number of trials have shown that therapies correcting dysbiosis, including fecal microbiota transplantation and probiotics, are promising in IBD.

本文言語English
ページ(範囲)47-55
ページ数9
ジャーナルSeminars in Immunopathology
37
1
DOI
出版ステータスPublished - 2015 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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