The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: A retrospective multicentre study

Simona Bota, Ioan Sporea, Markus Peck-Radosavljevic, Roxana Sirli, Hironori Tanaka, Hiroko Iijima, Hidetsugu Saito, Hirotoshi Ebinuma, Monica Lupsor, Radu Badea, Carmen Fierbinteanu-Braticevici, Ana Petrisor, Mireen Friedrich-Rust, Christoph Sarrazin, Hirokazu Takahashi, Naofumi Ono, Fabio Piscaglia, Sara Marinelli, Mirko D'Onofrio, Anna GallottiPetra Salzl, Alina Popescu, Mirela Danila

研究成果: Article査読

61 被引用数 (Scopus)

抄録

Background: Acoustic Radiation Force Impulse Elastography is a new method for non-invasive evaluation of liver fibrosis. Aim: To evaluate the impact of elevated alanine aminotransferase levels on liver stiffness assessment by Acoustic Radiation Force Impulse Elastography. Methods: A multicentre retrospective study including 1242 patients with chronic liver disease, who underwent liver biopsy and Acoustic Radiation Force Impulse. Transient Elastography was also performed in 512 patients. Results: The best Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis was 1.29. m/s in cases with normal alanine aminotransferase levels and 1.44. m/s in patients with alanine aminotransferase levels. >. 5× the upper limit of normal. The best cut-off for predicting liver cirrhosis were 1.59 and 1.75. m/s, respectively.Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis and cirrhosis were relatively similar in patients with normal alanine aminotransferase and in those with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal: 1.29. m/s vs. 1.36. m/s and 1.59. m/s vs. 1.57. m/s, respectively.For predicting cirrhosis, the Transient Elastography cut-offs were significantly higher in patients with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal compared to those with normal alanine aminotransferase: 12.3. kPa vs. 9.1. kPa. Conclusion: Liver stiffness values assessed by Acoustic Radiation Force Impulse and Transient Elastography are influenced by high aminotransferase levels. Transient Elastography was also influenced by moderately elevated aminotransferase levels.

本文言語English
ページ(範囲)762-768
ページ数7
ジャーナルDigestive and Liver Disease
45
9
DOI
出版ステータスPublished - 2013 9
外部発表はい

ASJC Scopus subject areas

  • 肝臓学
  • 消化器病学

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