The influence of cefotaxime on intestinal flora and bleeding diathesis in infants and neonates, compared with other β-lactams

K. Sunakawa, H. Akita, S. Iwata, Y. Sato

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Various second- and third-generation cephem antibiotics were administered to infants 2 years of age or less. Excluding Streptococcus faecalis, which is resistant to cephems, all of the intestinal bacteria decreased in number, and in many cases these were replaced by yeasts. A positive reaction for protein induced by vitamin K absence or antagonism (PIVKA II) occurred in 25 to 63 % of the subjects administered cephems possessing a methylthiotetrazole group, but not in those dosed with cefotaxime or ceftazidime. The effects of cefotaxime and latamoxef (moxalactam) on platelet ADP aggregation were also investigated. When these drugs were administered to clinical patients, moxalactam showed stronger inhibition of aggregation than cefotaxime.

本文言語English
ページ(範囲)317-324
ページ数8
ジャーナルJournal of Antimicrobial Chemotherapy
14
DOI
出版ステータスPublished - 1984

ASJC Scopus subject areas

  • 薬理学
  • 微生物学(医療)
  • 感染症
  • 薬理学(医学)

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