TY - JOUR
T1 - The influence of cefprozil on intestinal bacterial flora
AU - Iwata, Satoshi
AU - Ikeda, Masahiro
AU - Yamada, Kenichiro
AU - Isohata, Eiichi
AU - Kin, Yoshiaki
AU - Kusumoto, Yutaka
AU - Sato, Yoshitake
AU - Akita, Hlronobu
AU - Nanri, Seiichiro
AU - Oikawa, Tadao
AU - Yokota, Takao
AU - Sunakawa, Keisuke
AU - Ichihashi, Yasuo
PY - 1992/1
Y1 - 1992/1
N2 - Cefprozil (CFPZ, BMY-28100), a new oral cephalosporin antibiotic, was studied for its effect on the intestinal bacterial flora in pediatric patients. The subjects were children admitted for infections (2 males and 2 females, 9 months to 6 years 3 months old, weighed 4.3 to 19.0 kg). CFPZ granule was orally administered at a dose between 10.0 to 11.6mg/kg, 3 doses daily, over 4 to 14 days. The feces from these children were collected before, during and after administration, and bacteria were identified and counted. CFPZ concentration, β-lactamase activity were also assayed. Bacterial flora in feces during CFPZ administration showed some variance, but no significant change was observed in main aerobes and anaerobes. And in no case, glucose nonfermentative Gram-negative bacilli or fungi were found dominant. β-Lactamase activity was positive in the feces in all cases. CFPZ concentrations were not detectalbe in feces before, during and after administration. The above results suggest that CFPZ is a drug with little influence on the intestinal bacterial flora in children.
AB - Cefprozil (CFPZ, BMY-28100), a new oral cephalosporin antibiotic, was studied for its effect on the intestinal bacterial flora in pediatric patients. The subjects were children admitted for infections (2 males and 2 females, 9 months to 6 years 3 months old, weighed 4.3 to 19.0 kg). CFPZ granule was orally administered at a dose between 10.0 to 11.6mg/kg, 3 doses daily, over 4 to 14 days. The feces from these children were collected before, during and after administration, and bacteria were identified and counted. CFPZ concentration, β-lactamase activity were also assayed. Bacterial flora in feces during CFPZ administration showed some variance, but no significant change was observed in main aerobes and anaerobes. And in no case, glucose nonfermentative Gram-negative bacilli or fungi were found dominant. β-Lactamase activity was positive in the feces in all cases. CFPZ concentrations were not detectalbe in feces before, during and after administration. The above results suggest that CFPZ is a drug with little influence on the intestinal bacterial flora in children.
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U2 - 10.11553/antibiotics1968b.45.1474
DO - 10.11553/antibiotics1968b.45.1474
M3 - Article
C2 - 1494231
AN - SCOPUS:0027049869
VL - 45
SP - 1474
EP - 1488
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
SN - 0368-2781
IS - 11
ER -