The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

Yoriyoshi Kimurau, Hisashi Koga, Norie Araki, Norifumi Mugita, Naoyuki Fujita, Hideo Takeshima, Tohru Nishi, Tetsumori Yamashima, Takaomi C. Saido, Toshiki Yamasaki, Kouzo Moritake, Hideyuki Saya, Mitsuyoshi Nakao

研究成果: Article査読

102 被引用数 (Scopus)

抄録

Neurofibromatosis type 2 (NF2) protein, also known as merlin or schwannomin, is a tumor suppressor, and NF2 is mutated in most schwannomas and meningiomas. Although these tumors are dependent on NF2, some lack detectable NF2 mutations, which indicates that alternative mechanisms exist for inactivating merlin. Here, we demonstrate cleavage of merlin by the ubiquitous protease calpain and considerable activation of the calpain system resulting in the loss of merlin expression in these tumors. Increased proteolysis of merlin by calpain in some schwannomas and meningiomas exemplifies tumorigenesis linked to the calpain-mediated proteolytic pathway.

本文言語English
ページ(範囲)915-922
ページ数8
ジャーナルNature medicine
4
8
DOI
出版ステータスPublished - 1998 8
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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