The isolation and synthesis of two novel N-acetyl glucosamine derivatives from Dictyostelium cellular slime molds which exhibit neurite outgrowth activity

Haruhisa Kikuchi, Jun Komiya, Yoshinori Saito, Jun Ichi Sekiya, Shigeyoshi Honma, Norimichi Nakahata, Yoshiteru Oshima

研究成果: Article査読

17 被引用数 (Scopus)

抄録

To clarify the diversity of secondary metabolites of Dictyostelium cellular slime molds and explore any biologically active substances which they may hold, constituents of two species were investigated. From a methanol extract of their fruit bodies, two novel acylated amino sugars were isolated, dictyoglucosamine A (1) from D. purpureum and dictyoglucosamine B (2) from D. discoideum. For further analysis, these compounds were then synthesized from N-acetyl-D-glucosamine. Biological evaluation of 1 and 2 showed they induce neuronal differentiation of rat pheochromocytoma (PC-12) cells.

本文言語English
ページ(範囲)1477-1480
ページ数4
ジャーナルTetrahedron Letters
43
8
DOI
出版ステータスPublished - 2002 2月 18
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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