The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: Its synthesis and immunomodulatory function

Yohei Arai, Shota Torigoe, Takanori Matsumaru, Sho Yamasaki, Yukari Fujimoto

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Ac1PIM1is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.

本文言語English
ページ(範囲)3659-3663
ページ数5
ジャーナルOrganic and Biomolecular Chemistry
18
19
DOI
出版ステータスPublished - 2020 5 21

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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