The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons

Tetsuji Mori, Zhang Yuxing, Hiromi Takaki, Mayumi Takeuchi, Ken Iseki, Seita Hagino, Jun Ichi Kitanaka, Motohiko Takemura, Hidemi Misawa, Masahito Ikawa, Masaru Okabe, Akio Wanaka

研究成果: Article査読

81 被引用数 (Scopus)

抄録

Basal forebrain cholinergic neurons (BFCNs) are involved in cognitive functions such as learning and memory, and are affected in several neurodegenerative diseases (e.g. Alzheimer's disease). Despite their importance, the molecular mechanisms of their development are not fully elucidated. A recent report demonstrated that some BFCNs in adult rat are positive for L3/Lhx8, a LIM homeobox transcription factor. To examine the function of L3/Lhx8 in the development of BFCNs, we generated L3/Lhx8 gene-disrupted mice. In these mice, cells expressing cholinergic neuron markers, such as choline acetyltransferase, vesicular acetylcholine transporter and p75 low-affinity NGF receptor, were markedly reduced in the basal forebrain, whereas other cholinergic neurons including brain stem and spinal motor neurons expressed the markers. Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs.

本文言語English
ページ(範囲)3129-3141
ページ数13
ジャーナルEuropean Journal of Neuroscience
19
12
DOI
出版ステータスPublished - 2004 6月 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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