The Limitation of Staged Repair in the Surgical Management of Congenital Complex Heart Anomalies with Aortic Arch Obstruction

Ryo Aeba, Toshiyuki Katogi, Kenichi Hashizume, Yoshimi Iino, Kiyoshi Koizumi, Kentaro Hotoda, Shinya Inoue, Hideki Matayoshi, Akihiro Yoshitake, Ryohei Yozu

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Objective: Severe aortic arch obstruction including an interrupted aortic arch in congenital complex heart anomalies remains a challenge in surgical management. Methods: Treatment and outcomes in 75 consecutive patients who underwent an aortic arch repair as the first step of the staged repair protocol between 1975 and 2000 were reviewed. Their ages at repair ranged from 1 day to 8.5 months. Results: Cross-sectional postoperative follow-up data were available in all the patients. The follow-up period ranged from 0 to 27.6 years (mean: 7.3 ± 7.3 years). There were 20 postoperative hospital deaths (27%) and 7 late deaths. The Kaplan-Meier estimate of survival was 81.3% ± 4.5% at 1 month, 68.0% ± 5.4% at 1 year, 65.0% ± 5.5% at 5 years, 63.1% ± 5.7% at 10 years, 63.1% ± 5.7% at 20 years. By Cox regression analysis, body weight of 2.5 kg or less is the only independent determinant of postoperative mortality (p = 0.04, multivariable odds ratio: 2.50, [95% confidence interval: 1.02-6.1]). The aortic arch morphology, the primary cardiac lesion, or date of operation did not reach a statistically significant level to show correlation with mortality. Reintervention to reconstruct the aortic arch was performed at 9 occasions in 8 of the 55 patients who survived the primary operation (14.5%). The Kaplan-Meier estimate of the reintervention-free rate was 91.3% ± 4.2% at 5 years, 85.5% ± 5.6% at 10 years, 75.6% ± 8.2% at 20 years. Using multivariable Cox regression analysis, interrupted aortic arch (versus aortic coarctation) was the only independent predictor of a shorter time to reintervention (p = 0.001, multivariable odds ratio: 16.1, [95% confidence interval: 3.2-80.2]). Conclusions: The staged repair protocol was associated with significant limitations in patient survival and with the development of recurrent aortic arch obstruction. Thus, a primary repair protocol may serve as an alternate approach, especially in patients with low weight or with an interrupted aortic arch.

本文言語English
ページ(範囲)302-307
ページ数6
ジャーナルJapanese Journal of Thoracic and Cardiovascular Surgery
51
7
DOI
出版ステータスPublished - 2003 7

ASJC Scopus subject areas

  • 循環器および心血管医学

フィンガープリント

「The Limitation of Staged Repair in the Surgical Management of Congenital Complex Heart Anomalies with Aortic Arch Obstruction」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル