The lung as a possible target organ for atrial natriuretic polypeptide secreted from the heart

Makoto Sakamoto, Kazuwa Nakao, Narito Morii, Akira Sugawara, Takayuki Yamada, Hiroshi Itoh, Shozo Shiono, Yoshihiko Saito, Hiroo Imura

研究成果: Article査読

54 被引用数 (Scopus)

抄録

Using a specific radioimmunoassay (RIA) for α-rat atrial natriuretic polypeptide (α-rANP), we have demonstrated the presence of a considerable amount (6.10 ± 0.38 ng/g) (mean ± SE) of α-rANP-like immunoreactivity (α-rANP-LI) in the rat lung, the first organ through which atrial natriuretic polypeptide (ANP) released from the heart passes. High performance gel permeation chromatography coupled with the RIA revealed that most of α-rANP-LI eluted at the position of a low molecular weight form corresponding to synthetic α-rANP. In 2- or 5-day water-deprived rats, the concentration and content of α-rANP-LI in the lung decreased significantly compared with those of control rats. In addition, water-deprivation induced a significant decrease in the plasma concentration of α-rANP-LI simultaneously determined. There was a significant positive correlation between the concentrations of α-rANP-LI in the lung and plasma (r=0.591, P<0.01). These results indicate the presence of ANP in the lung and suggest physiological roles of ANP in pulmonary function.

本文言語English
ページ(範囲)515-520
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
135
2
DOI
出版ステータスPublished - 1986 3月 13
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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