The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation

Shiho Hakomori, Sayaka Ohmori, Kensuke Masuda, Kojiro Yamamoto, Tsunenori Arai

研究成果: Conference contribution

1 引用 (Scopus)

抜粋

In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.

元の言語English
ホスト出版物のタイトルOptical Methods for Tumor Treatment and Detection
ホスト出版物のサブタイトルMechanisms and Techniques in Photodynamic Therapy XV
DOI
出版物ステータスPublished - 2007 8 31
イベントOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI - San Jose, CA, United States
継続期間: 2007 1 202007 1 21

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6427
ISSN(印刷物)1605-7422

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
United States
San Jose, CA
期間07/1/2007/1/21

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

フィンガープリント The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Hakomori, S., Ohmori, S., Masuda, K., Yamamoto, K., & Arai, T. (2007). The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. : Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV [642715] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; 巻数 6427). https://doi.org/10.1117/12.699857