@inproceedings{7f0f92f32f5043cc8e79947efeb2e448,
title = "The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II){\textregistered} and Talaporfin Sodium with pulsed excitation",
abstract = "In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II){\textregistered} and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.",
keywords = "Phosphorescence, Photodynamic therapy, Photofrin(II){\textregistered}, Pulsed excitation, Singlet oxygen, Talaporfin sodium, Time-resolved waveform",
author = "Shiho Hakomori and Sayaka Ohmori and Kensuke Masuda and Kojiro Yamamoto and Tsunenori Arai",
year = "2007",
month = aug,
day = "31",
doi = "10.1117/12.699857",
language = "English",
isbn = "0819465402",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Methods for Tumor Treatment and Detection",
note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI ; Conference date: 20-01-2007 Through 21-01-2007",
}