The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation

Shiho Hakomori, Sayaka Ohmori, Kensuke Masuda, Kojiro Yamamoto, Tsunenori Arai

研究成果: Conference contribution

1 引用 (Scopus)

抄録

In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.

元の言語English
ホスト出版物のタイトルProgress in Biomedical Optics and Imaging - Proceedings of SPIE
6427
DOI
出版物ステータスPublished - 2007
イベントOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI - San Jose, CA, United States
継続期間: 2007 1 202007 1 21

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
United States
San Jose, CA
期間07/1/2007/1/21

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Phosphorescence
Photosensitizers
Fluorescence
Sodium
Oxygen
Photodynamic therapy
Ground state
Luminescence
Photons

ASJC Scopus subject areas

  • Engineering(all)

これを引用

Hakomori, S., Ohmori, S., Masuda, K., Yamamoto, K., & Arai, T. (2007). The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. : Progress in Biomedical Optics and Imaging - Proceedings of SPIE (巻 6427). [642715] https://doi.org/10.1117/12.699857

The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. / Hakomori, Shiho; Ohmori, Sayaka; Masuda, Kensuke; Yamamoto, Kojiro; Arai, Tsunenori.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 巻 6427 2007. 642715.

研究成果: Conference contribution

Hakomori, S, Ohmori, S, Masuda, K, Yamamoto, K & Arai, T 2007, The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. : Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 巻. 6427, 642715, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, San Jose, CA, United States, 07/1/20. https://doi.org/10.1117/12.699857
Hakomori S, Ohmori S, Masuda K, Yamamoto K, Arai T. The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. : Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 巻 6427. 2007. 642715 https://doi.org/10.1117/12.699857
Hakomori, Shiho ; Ohmori, Sayaka ; Masuda, Kensuke ; Yamamoto, Kojiro ; Arai, Tsunenori. / The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 巻 6427 2007.
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AU - Yamamoto, Kojiro

AU - Arai, Tsunenori

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N2 - In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.

AB - In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.

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