抄録
In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.
| 元の言語 | English |
|---|---|
| ホスト出版物のタイトル | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| 巻 | 6427 |
| DOI | |
| 出版物ステータス | Published - 2007 |
| イベント | Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI - San Jose, CA, United States 継続期間: 2007 1 20 → 2007 1 21 |
Other
| Other | Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI |
|---|---|
| 国 | United States |
| 市 | San Jose, CA |
| 期間 | 07/1/20 → 07/1/21 |
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ASJC Scopus subject areas
- Engineering(all)
これを引用
The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation. / Hakomori, Shiho; Ohmori, Sayaka; Masuda, Kensuke; Yamamoto, Kojiro; Arai, Tsunenori.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 巻 6427 2007. 642715.研究成果: Conference contribution
}
TY - GEN
T1 - The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II)® and Talaporfin Sodium with pulsed excitation
AU - Hakomori, Shiho
AU - Ohmori, Sayaka
AU - Masuda, Kensuke
AU - Yamamoto, Kojiro
AU - Arai, Tsunenori
PY - 2007
Y1 - 2007
N2 - In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.
AB - In order to investigate the interaction between the triplet state T 1 and ground state oxygen 3O2 during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen 1O2 fluorescence timeresolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)® and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The 1O2 fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms.
KW - Phosphorescence
KW - Photodynamic therapy
KW - Photofrin(II)®
KW - Pulsed excitation
KW - Singlet oxygen
KW - Talaporfin sodium
KW - Time-resolved waveform
UR - http://www.scopus.com/inward/record.url?scp=34548261828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548261828&partnerID=8YFLogxK
U2 - 10.1117/12.699857
DO - 10.1117/12.699857
M3 - Conference contribution
AN - SCOPUS:34548261828
SN - 0819465402
SN - 9780819465405
VL - 6427
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ER -