The microbiota in adaptive immune homeostasis and disease

Kenya Honda, Dan R. Littman

研究成果: Review article査読

743 被引用数 (Scopus)

抄録

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota-host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.

本文言語English
ページ(範囲)75-84
ページ数10
ジャーナルNature
535
7610
DOI
出版ステータスPublished - 2016 7 6

ASJC Scopus subject areas

  • 一般

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