The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus

Tomohiro Suhara, Yuichi Baba, Briana K. Shimada, Jason K. Higa, Takashi Matsui

研究成果: Review article

15 引用 (Scopus)

抄録

Purpose of Review: T2DM (type 2 diabetes mellitus) is a risk factor for heart failure. The mTOR (mechanistic target of rapamycin) is a key mediator of the insulin signaling pathway. We will discuss the role of mTOR in myocardial dysfunction in T2DM. Recent Findings: In T2DM, chronically activated mTOR induces multiple pathological events, including a negative feedback loop that suppresses IRS (insulin receptor substrate)-1. While short-term treatment with rapamycin, an mTOR inhibitor, is a promising strategy for cardiac diseases such as acute myocardial infarction and cardiac hypertrophy in T2DM, there are many concerns about chronic usage of rapamycin. Two mTOR complexes, mTORC1 and mTORC2, affect many molecules and processes via distinct signaling pathways that regulate cardiomyocyte function and survival. Summary: Understanding mechanisms underlying mTOR-mediated pathophysiological features in the heart is essential for developing effective therapies for cardiac diseases in the context of T2DM.

元の言語English
記事番号38
ジャーナルCurrent Diabetes Reports
17
発行部数6
DOI
出版物ステータスPublished - 2017 6 1

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Sirolimus
Type 2 Diabetes Mellitus
Heart Diseases
Insulin Receptor Substrate Proteins
Cardiomegaly
Cardiac Myocytes
Heart Failure
Myocardial Infarction
Insulin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

これを引用

The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus. / Suhara, Tomohiro; Baba, Yuichi; Shimada, Briana K.; Higa, Jason K.; Matsui, Takashi.

:: Current Diabetes Reports, 巻 17, 番号 6, 38, 01.06.2017.

研究成果: Review article

Suhara, Tomohiro ; Baba, Yuichi ; Shimada, Briana K. ; Higa, Jason K. ; Matsui, Takashi. / The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus. :: Current Diabetes Reports. 2017 ; 巻 17, 番号 6.
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