The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock

Maiko Moriyama, Akihiro Matsukawa, Shinji Kudoh, Tomoko Takahashi, Takahiro Sato, Tatsuhiko Kano, Akihiko Yoshimura, Masayasu Kojima

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Neuromedin U (NMU) is a neuropeptide involved in appetite, circadian rhythm, and pronociception. However, the NMU receptor NMU-R1 has been shown to be expressed in immune cells and NMU promotes mast cell-dependent inflammation. In this study, we demonstrated that NMU plays an important role in IL-6 production in macrophages. NMU-deficient mice were resistant against cecal ligation puncture- as well as LPS-induced septic shock. IL-6 but not TNF-α levels were markedly reduced in LPS-treated NMU-deficient mice compared with wild type mice. Both NMU and NMU-R1 were expressed in wild type peritoneal macrophages, and treatment with LPS resulted in up-regulation of NMU but down-regulation of NMU-R1 expression, however, no down-regulation of NMU-R1 was observed in NMU-deficient macrophages where LPS-induced IL-6 production was severely reduced. These data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages.

本文言語English
ページ(範囲)1149-1154
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
341
4
DOI
出版ステータスPublished - 2006 3 24
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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