The organization of the human immunoglobulin λ gene locus

K. Kawasaki, S. Minoshima, K. Schooler, Jun Kudo, S. Asakawa, P. J. De Jong, N. Shimizu

研究成果: Article

44 引用 (Scopus)


To elucidate the complex structure of the human immunoglobulin λ gene locus, a 1020-kb contig was constructed using 184 cosmid clones and one bacterial artificial chromosome (BAC) clone. A high-resolution physical map of this contig revealed that the entire λ gene locus is 911 kb in length. It contains seven constant region (C(λ)) gene segments and 69 unique EcoRI-HindIII segments that hybridize to variable region gene (V(λ) probes. The VpreB gene, BCRL4, and γ-glutamyl transpeptidase gene (GGT)-like sequences are also located within the λ gene locus. Hybridization analysis suggested that the λ gene locus has undergone extensive amplification events in evolution.

ジャーナルGenome Research
出版物ステータスPublished - 1995


ASJC Scopus subject areas

  • Genetics


Kawasaki, K., Minoshima, S., Schooler, K., Kudo, J., Asakawa, S., De Jong, P. J., & Shimizu, N. (1995). The organization of the human immunoglobulin λ gene locus. Genome Research, 5(2), 125-135.