The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects

K. Nakao; A. Sugawara; N. Morii; M. Sakamoto; T. Yamada; H. Itoh; S. Shiono; Y. Saito; K. Nishimura; T. Ban; K. Kangawa; H. Matsuo; H. Imura

doi:10.1007/BF00870995

The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects

K. Nakao, A. Sugawara, N. Morii, M. Sakamoto, T. Yamada, H. Itoh, S. Shiono, Y. Saito, K. Nishimura, T. Ban, K. Kangawa, H. Matsuo, H. Imura

研究成果: Article › 査読

42 被引用数 (Scopus)

抄録

We have analysed the pharmacokinetics of α-human atrial natriuretic polypeptide (α-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7±0.07 min and 13.3±1.69 min respectively. V₁ (the volume of the central compartment), V_z (volume of distribution) and V_ss (volume of distribution at steady-state) were 5370±855 ml (89.5±14.3 ml·kg^-1), 32000±4620 ml (533±77.0 ml·kg^-1), and 11900±1530 ml (198±25.5 ml·kg^-1) respectively. The mean plasma clearance was 1520±121 ml·min^-1 (25.4±2.0 ml·min^-1·kg^-1.

本文言語	English
ページ（範囲）	101-103
ページ数	3
ジャーナル	European Journal of Clinical Pharmacology
巻	31
号	1
DOI	https://doi.org/10.1007/BF00870995
出版ステータス	Published - 1986 1月 1
外部発表	はい

ASJC Scopus subject areas

薬理学
薬理学（医学）

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1007/BF00870995

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title = "The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects",

abstract = "We have analysed the pharmacokinetics of α-human atrial natriuretic polypeptide (α-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7±0.07 min and 13.3±1.69 min respectively. V1 (the volume of the central compartment), Vz (volume of distribution) and Vss (volume of distribution at steady-state) were 5370±855 ml (89.5±14.3 ml·kg-1), 32000±4620 ml (533±77.0 ml·kg-1), and 11900±1530 ml (198±25.5 ml·kg-1) respectively. The mean plasma clearance was 1520±121 ml·min-1 (25.4±2.0 ml·min-1·kg-1.",

keywords = "atrial natriuretic polypeptide, pharmacokinetics, radioimmunassay, α-hANP",

author = "K. Nakao and A. Sugawara and N. Morii and M. Sakamoto and T. Yamada and H. Itoh and S. Shiono and Y. Saito and K. Nishimura and T. Ban and K. Kangawa and H. Matsuo and H. Imura",

year = "1986",

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doi = "10.1007/BF00870995",

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T1 - The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects

AU - Nakao, K.

AU - Sugawara, A.

AU - Morii, N.

AU - Sakamoto, M.

AU - Yamada, T.

AU - Itoh, H.

AU - Shiono, S.

AU - Saito, Y.

AU - Nishimura, K.

AU - Ban, T.

AU - Kangawa, K.

AU - Matsuo, H.

AU - Imura, H.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - We have analysed the pharmacokinetics of α-human atrial natriuretic polypeptide (α-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7±0.07 min and 13.3±1.69 min respectively. V1 (the volume of the central compartment), Vz (volume of distribution) and Vss (volume of distribution at steady-state) were 5370±855 ml (89.5±14.3 ml·kg-1), 32000±4620 ml (533±77.0 ml·kg-1), and 11900±1530 ml (198±25.5 ml·kg-1) respectively. The mean plasma clearance was 1520±121 ml·min-1 (25.4±2.0 ml·min-1·kg-1.

AB - We have analysed the pharmacokinetics of α-human atrial natriuretic polypeptide (α-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7±0.07 min and 13.3±1.69 min respectively. V1 (the volume of the central compartment), Vz (volume of distribution) and Vss (volume of distribution at steady-state) were 5370±855 ml (89.5±14.3 ml·kg-1), 32000±4620 ml (533±77.0 ml·kg-1), and 11900±1530 ml (198±25.5 ml·kg-1) respectively. The mean plasma clearance was 1520±121 ml·min-1 (25.4±2.0 ml·min-1·kg-1.

KW - atrial natriuretic polypeptide

KW - pharmacokinetics

KW - radioimmunassay

KW - α-hANP

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The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects

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ASJC Scopus subject areas

UN SDG

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