The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases

Shigeki Ota, Ophelia Veraitch, Hideyuki Okano, Manabu Ohyama, Yutaka Kawakami

研究成果: Chapter

1 引用 (Scopus)

抄録

The seminal discovery of induced pluripotent stem cells (iPSCs) and subsequent expansion in iPSC research have greatly aided our understanding of stem cell biology and have catapulted the changing face of regenerative medicine into prominence. With easy accessibility and visibility, the skin has been considered a favorable organ to study stem cell behaviors. In particular, the skin provides valuable materials for tissue engineering and testing of novel therapeutic approaches including gene therapy and regenerative medicine. The skin consists of multiple cell lineages, including interfollicular/follicular keratinocytes, melanocytes, sebocytes, and follicular/intradermal mesenchymal cells. Nowadays, iPSCs can be generated from various skin-derived cell populations. Elegant label-tracking experiments have successfully identified their stem/early precursor cell populations. Following molecular and cellular biological experimentations and transgenic studies the elucidation of necessary factors, signaling networks, environments supporting their behavior, and interactions in organogenesis and homeostasis have been uncovered. Taking advantage of the knowledge accumulated by these works, iPSC-derived keratinocytes and melanocytes have been successfully induced, which holds promise as future materials for the bioengineering of the skin and hair, and investigation of biology of skin stem cells. Recently, the concept of cancer stem cells (CSCs) has been proposed. Cancer stem cells have been implied to originate from stem cell subsets and, accordingly, iPSCs may be converted to skin CSCs, especially most life-threatening melanoma CSCs. Those iPSC-derived CSCs may significantly enhance our understanding of cancer biology and allow the development of novel therapeutic strategies. Recently, patient-specific iPSCs were established from intractable genodermatoses, including epidermolysis bullosa, and corrected for their genetic defects. Thus, iPSC technology should open a new era of stem cell biology, genetic/regenerative medicine and oncology in the field of dermatology.

元の言語English
ホスト出版物のタイトルCell and Molecular Biology and Imaging of Stem Cells
出版者Wiley Blackwell
ページ223-245
ページ数23
ISBN(印刷物)9781118285602, 9781118284100
DOI
出版物ステータスPublished - 2014 11 10

Fingerprint

Induced Pluripotent Stem Cells
Stem cells
Skin Diseases
Skin
Neoplastic Stem Cells
Stem Cells
Regenerative Medicine
Melanocytes
Keratinocytes
Cell Biology
Epidermolysis Bullosa
Stem Cell Research
Cytology
Bioengineering
Organogenesis
Skin Neoplasms
Cell Lineage
Tissue Engineering
Dermatology
Genetic Therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Ota, S., Veraitch, O., Okano, H., Ohyama, M., & Kawakami, Y. (2014). The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases. : Cell and Molecular Biology and Imaging of Stem Cells (pp. 223-245). Wiley Blackwell. https://doi.org/10.1002/9781118285602.ch10

The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases. / Ota, Shigeki; Veraitch, Ophelia; Okano, Hideyuki; Ohyama, Manabu; Kawakami, Yutaka.

Cell and Molecular Biology and Imaging of Stem Cells. Wiley Blackwell, 2014. p. 223-245.

研究成果: Chapter

Ota, S, Veraitch, O, Okano, H, Ohyama, M & Kawakami, Y 2014, The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases. : Cell and Molecular Biology and Imaging of Stem Cells. Wiley Blackwell, pp. 223-245. https://doi.org/10.1002/9781118285602.ch10
Ota S, Veraitch O, Okano H, Ohyama M, Kawakami Y. The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases. : Cell and Molecular Biology and Imaging of Stem Cells. Wiley Blackwell. 2014. p. 223-245 https://doi.org/10.1002/9781118285602.ch10
Ota, Shigeki ; Veraitch, Ophelia ; Okano, Hideyuki ; Ohyama, Manabu ; Kawakami, Yutaka. / The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases. Cell and Molecular Biology and Imaging of Stem Cells. Wiley Blackwell, 2014. pp. 223-245
@inbook{ec7a824e6ed542bbb5288ea08c399eae,
title = "The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases",
abstract = "The seminal discovery of induced pluripotent stem cells (iPSCs) and subsequent expansion in iPSC research have greatly aided our understanding of stem cell biology and have catapulted the changing face of regenerative medicine into prominence. With easy accessibility and visibility, the skin has been considered a favorable organ to study stem cell behaviors. In particular, the skin provides valuable materials for tissue engineering and testing of novel therapeutic approaches including gene therapy and regenerative medicine. The skin consists of multiple cell lineages, including interfollicular/follicular keratinocytes, melanocytes, sebocytes, and follicular/intradermal mesenchymal cells. Nowadays, iPSCs can be generated from various skin-derived cell populations. Elegant label-tracking experiments have successfully identified their stem/early precursor cell populations. Following molecular and cellular biological experimentations and transgenic studies the elucidation of necessary factors, signaling networks, environments supporting their behavior, and interactions in organogenesis and homeostasis have been uncovered. Taking advantage of the knowledge accumulated by these works, iPSC-derived keratinocytes and melanocytes have been successfully induced, which holds promise as future materials for the bioengineering of the skin and hair, and investigation of biology of skin stem cells. Recently, the concept of cancer stem cells (CSCs) has been proposed. Cancer stem cells have been implied to originate from stem cell subsets and, accordingly, iPSCs may be converted to skin CSCs, especially most life-threatening melanoma CSCs. Those iPSC-derived CSCs may significantly enhance our understanding of cancer biology and allow the development of novel therapeutic strategies. Recently, patient-specific iPSCs were established from intractable genodermatoses, including epidermolysis bullosa, and corrected for their genetic defects. Thus, iPSC technology should open a new era of stem cell biology, genetic/regenerative medicine and oncology in the field of dermatology.",
keywords = "Cancer stem cells, Induced pluripotent stem cells (iPSCs), Keratinocytes, Melanocytes",
author = "Shigeki Ota and Ophelia Veraitch and Hideyuki Okano and Manabu Ohyama and Yutaka Kawakami",
year = "2014",
month = "11",
day = "10",
doi = "10.1002/9781118285602.ch10",
language = "English",
isbn = "9781118285602",
pages = "223--245",
booktitle = "Cell and Molecular Biology and Imaging of Stem Cells",
publisher = "Wiley Blackwell",

}

TY - CHAP

T1 - The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases

AU - Ota, Shigeki

AU - Veraitch, Ophelia

AU - Okano, Hideyuki

AU - Ohyama, Manabu

AU - Kawakami, Yutaka

PY - 2014/11/10

Y1 - 2014/11/10

N2 - The seminal discovery of induced pluripotent stem cells (iPSCs) and subsequent expansion in iPSC research have greatly aided our understanding of stem cell biology and have catapulted the changing face of regenerative medicine into prominence. With easy accessibility and visibility, the skin has been considered a favorable organ to study stem cell behaviors. In particular, the skin provides valuable materials for tissue engineering and testing of novel therapeutic approaches including gene therapy and regenerative medicine. The skin consists of multiple cell lineages, including interfollicular/follicular keratinocytes, melanocytes, sebocytes, and follicular/intradermal mesenchymal cells. Nowadays, iPSCs can be generated from various skin-derived cell populations. Elegant label-tracking experiments have successfully identified their stem/early precursor cell populations. Following molecular and cellular biological experimentations and transgenic studies the elucidation of necessary factors, signaling networks, environments supporting their behavior, and interactions in organogenesis and homeostasis have been uncovered. Taking advantage of the knowledge accumulated by these works, iPSC-derived keratinocytes and melanocytes have been successfully induced, which holds promise as future materials for the bioengineering of the skin and hair, and investigation of biology of skin stem cells. Recently, the concept of cancer stem cells (CSCs) has been proposed. Cancer stem cells have been implied to originate from stem cell subsets and, accordingly, iPSCs may be converted to skin CSCs, especially most life-threatening melanoma CSCs. Those iPSC-derived CSCs may significantly enhance our understanding of cancer biology and allow the development of novel therapeutic strategies. Recently, patient-specific iPSCs were established from intractable genodermatoses, including epidermolysis bullosa, and corrected for their genetic defects. Thus, iPSC technology should open a new era of stem cell biology, genetic/regenerative medicine and oncology in the field of dermatology.

AB - The seminal discovery of induced pluripotent stem cells (iPSCs) and subsequent expansion in iPSC research have greatly aided our understanding of stem cell biology and have catapulted the changing face of regenerative medicine into prominence. With easy accessibility and visibility, the skin has been considered a favorable organ to study stem cell behaviors. In particular, the skin provides valuable materials for tissue engineering and testing of novel therapeutic approaches including gene therapy and regenerative medicine. The skin consists of multiple cell lineages, including interfollicular/follicular keratinocytes, melanocytes, sebocytes, and follicular/intradermal mesenchymal cells. Nowadays, iPSCs can be generated from various skin-derived cell populations. Elegant label-tracking experiments have successfully identified their stem/early precursor cell populations. Following molecular and cellular biological experimentations and transgenic studies the elucidation of necessary factors, signaling networks, environments supporting their behavior, and interactions in organogenesis and homeostasis have been uncovered. Taking advantage of the knowledge accumulated by these works, iPSC-derived keratinocytes and melanocytes have been successfully induced, which holds promise as future materials for the bioengineering of the skin and hair, and investigation of biology of skin stem cells. Recently, the concept of cancer stem cells (CSCs) has been proposed. Cancer stem cells have been implied to originate from stem cell subsets and, accordingly, iPSCs may be converted to skin CSCs, especially most life-threatening melanoma CSCs. Those iPSC-derived CSCs may significantly enhance our understanding of cancer biology and allow the development of novel therapeutic strategies. Recently, patient-specific iPSCs were established from intractable genodermatoses, including epidermolysis bullosa, and corrected for their genetic defects. Thus, iPSC technology should open a new era of stem cell biology, genetic/regenerative medicine and oncology in the field of dermatology.

KW - Cancer stem cells

KW - Induced pluripotent stem cells (iPSCs)

KW - Keratinocytes

KW - Melanocytes

UR - http://www.scopus.com/inward/record.url?scp=84926405414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926405414&partnerID=8YFLogxK

U2 - 10.1002/9781118285602.ch10

DO - 10.1002/9781118285602.ch10

M3 - Chapter

AN - SCOPUS:84926405414

SN - 9781118285602

SN - 9781118284100

SP - 223

EP - 245

BT - Cell and Molecular Biology and Imaging of Stem Cells

PB - Wiley Blackwell

ER -