The prevalence & risk factors of dementia in centenarians

研究成果: Article

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Centenarians are less susceptible to the diseases, functional losses and dependencies related to old age than the general public, and are therefore regarded as model cases of successful aging. For this reason, an important focus of the study of centenarians is their relative resilience to age-related cognitive decline or dementia. In the Tokyo Centenarian Study, we found approximately 60% of centenarians to have dementia; however, supercentenarians (those people living at least 110 years) maintained normal cognitive function at 100 years of age. Our preliminary data also demonstrated extremely low frequencies of the apolipoprotein E4 allele in supercentenarians. Moreover, postmortem brain samples from supercentenarians demonstrated relatively mild age- related neuropathological findings. Therefore, a more extensive investigation of supercentenarian populations might provide insight into successful brain aging.

元の言語English
ページ(範囲)771-780
ページ数10
ジャーナルBrain and Nerve
69
発行部数7
出版物ステータスPublished - 2017 7 1

ASJC Scopus subject areas

  • Clinical Neurology

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