The recipient CCR5 variation predicts survival outcomes after bone marrow transplantation

Tomohiro Horio, Shohei Mizuno, Kaori Uchino, Motonori Mizutani, Ichiro Hanamura, J. Luis Espinoza, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura, Takehiko Mori, Akiyoshi Takami

研究成果: Article

3 引用 (Scopus)

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The chemokine receptor CCR5 plays roles in the trafficking of effector cells towards the site of inflammation. We retrospectively examined the impact of the CCR5 variation (rs1800023, -2086A > G) on transplant outcomes in a cohort of 329 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. A multivariate analysis showed that the recipient CCR5 -2086A/A genotype was significantly associated with a lower relapse rate but not with the development of graft-versus-host disease (GVHD) or transplant-related mortality, thereby resulting in better disease-free and overall survival rates than other variations. The donor CCR5 -2086A/A genotype was associated with a lower incidence of grades 3–4 acute GVHD, which did not improve the survival outcomes. These findings suggest that the recipient CCR5 -2086A/A genotype affects the induction of the graft-versus-tumor effect without augmenting the development of GVHD. CCR5 genotyping in transplant recipients may therefore be a useful tool for evaluating pretransplantation risks.

元の言語English
ページ(範囲)34-39
ページ数6
ジャーナルTransplant Immunology
42
DOI
出版物ステータスPublished - 2017 6

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

フィンガープリント The recipient CCR5 variation predicts survival outcomes after bone marrow transplantation' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Horio, T., Mizuno, S., Uchino, K., Mizutani, M., Hanamura, I., Espinoza, J. L., Onizuka, M., Kashiwase, K., Morishima, Y., Fukuda, T., Kodera, Y., Doki, N., Miyamura, K., Mori, T., & Takami, A. (2017). The recipient CCR5 variation predicts survival outcomes after bone marrow transplantation. Transplant Immunology, 42, 34-39. https://doi.org/10.1016/j.trim.2017.05.003