The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells

Medicine & Life Sciences

• Acetates 5%
• Acids 33%
• Cell Line 3%
• Cysteine 10%
• Extracellular Signal-Regulated MAP Kinases 48%
• Growth 5%
• hypothemycin 100%
• Intercellular Signaling Peptides and Proteins 4%
• Kidney 9%
• Lactones 57%
• MAP Kinase Kinase Kinases 7%
• Mitogen-Activated Protein Kinase Kinases 48%
• Neoplasms 1%
• Phenotype 3%
• phorbol-12-myristate 6%
• Phosphatidylinositol 3-Kinase 5%
• Phosphotransferases 4%
• Platelet-Derived Growth Factor 6%
• Platelet-Derived Growth Factor Receptors 14%
• Protein Binding 5%
• Protein Kinases 20%
• U 0126 7%

Chemical Compounds

• Acid 15%
• Cysteine 9%
• EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 9%
• Environment 3%
• Hypothemycin 88%
• Lactone 42%
• Phorbol 13-Acetate 12-Myristate 8%
• Protein 18%
• U0126 10%