The RET proto-oncogene in sporadic pheochromocytomas

Kazuhiko Takaya, Takaaki Yoshimasa, Hiroshi Arai, Naohisa Tamura, Yoshihiro Miyamoto, Hiroshi Itoh, Kazuwa Nakao

研究成果: Article

10 引用 (Scopus)

抄録

In order to evaluate the role of RET proto-oncogene in the development and growth of pheochromocytomas, we examined mutations in RET and expression of RET in 7 cases of sporadic pheochromocytomas. Tumors were screened for mutations in exons 10 and 11 and codon 918 which are identified in multiple endocrine neoplasia types 2A and 2B. No mutations were found in these regions in all of the sporadic pheochromocytomas examined. On the other hand, RET mRNA was detected in all pheochromocytomas and the levels of RET expression were higher in 5 of 7 pheochromocytomas than in normal adrenal medulla, indicating that RET is overexpressed in a sizable portion of sporadic pheochromocytomas. These results suggest that high levels of expression of RET may have relevance to the development or growth of sporadic pheochromocytomas.

元の言語English
ページ(範囲)449-452
ページ数4
ジャーナルInternal Medicine
35
発行部数6
出版物ステータスPublished - 1996 6
外部発表Yes

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Proto-Oncogenes
Pheochromocytoma
Growth and Development
Mutation
Multiple Endocrine Neoplasia Type 2b
Multiple Endocrine Neoplasia Type 2a
Adrenal Medulla
Codon
Exons
Messenger RNA
Neoplasms

ASJC Scopus subject areas

  • Internal Medicine

これを引用

Takaya, K., Yoshimasa, T., Arai, H., Tamura, N., Miyamoto, Y., Itoh, H., & Nakao, K. (1996). The RET proto-oncogene in sporadic pheochromocytomas. Internal Medicine, 35(6), 449-452.

The RET proto-oncogene in sporadic pheochromocytomas. / Takaya, Kazuhiko; Yoshimasa, Takaaki; Arai, Hiroshi; Tamura, Naohisa; Miyamoto, Yoshihiro; Itoh, Hiroshi; Nakao, Kazuwa.

:: Internal Medicine, 巻 35, 番号 6, 06.1996, p. 449-452.

研究成果: Article

Takaya, K, Yoshimasa, T, Arai, H, Tamura, N, Miyamoto, Y, Itoh, H & Nakao, K 1996, 'The RET proto-oncogene in sporadic pheochromocytomas', Internal Medicine, 巻. 35, 番号 6, pp. 449-452.
Takaya K, Yoshimasa T, Arai H, Tamura N, Miyamoto Y, Itoh H その他. The RET proto-oncogene in sporadic pheochromocytomas. Internal Medicine. 1996 6;35(6):449-452.
Takaya, Kazuhiko ; Yoshimasa, Takaaki ; Arai, Hiroshi ; Tamura, Naohisa ; Miyamoto, Yoshihiro ; Itoh, Hiroshi ; Nakao, Kazuwa. / The RET proto-oncogene in sporadic pheochromocytomas. :: Internal Medicine. 1996 ; 巻 35, 番号 6. pp. 449-452.
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AU - Itoh, Hiroshi

AU - Nakao, Kazuwa

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AB - In order to evaluate the role of RET proto-oncogene in the development and growth of pheochromocytomas, we examined mutations in RET and expression of RET in 7 cases of sporadic pheochromocytomas. Tumors were screened for mutations in exons 10 and 11 and codon 918 which are identified in multiple endocrine neoplasia types 2A and 2B. No mutations were found in these regions in all of the sporadic pheochromocytomas examined. On the other hand, RET mRNA was detected in all pheochromocytomas and the levels of RET expression were higher in 5 of 7 pheochromocytomas than in normal adrenal medulla, indicating that RET is overexpressed in a sizable portion of sporadic pheochromocytomas. These results suggest that high levels of expression of RET may have relevance to the development or growth of sporadic pheochromocytomas.

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