The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches

R. Iiyama, T. Kanai, K. Uraushihara, T. Totsuka, T. Nakamura, T. Miyata, H. Yagita, A. Kushi, K. Suzuki, K. Tezuka, M. Watanabe

研究成果: Article査読

10 被引用数 (Scopus)

抄録

T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interactions play an essential role of T-cell-dependent B-cell activation in peripheral lymphoid organs such as spleen and lymph nodes. Here, we investigate the role of ICOS/B7RP-1 interactions in the development of Peyer's patches (PPs). In ICOS-/- mice, the number of PPs was not decreased, although PPs in ICOS-/- mice were significantly reduced in size. Phenotypic analysis showed no obvious differences between ICOS-/- and ICOS+/- mice in the distribution of T-cells, B-cells, macrophages and dendritic cells. However, PNA+ cells characteristic of intestinal germinal centers were totally absent in ICOS-/- mice. Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS-/- mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs.

本文言語English
ページ(範囲)63-70
ページ数8
ジャーナルImmunology Letters
88
1
DOI
出版ステータスPublished - 2003 7 3
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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