抄録
The novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties were designed and synthesized, and their DNA photocleaving abilities were evaluated in order to examine the effect of the disaccharide structures. The configurations of the glycosidic bonds in the disaccharide strongly affected the DNA photocleaving ability, and two β-glycosidic bond linkages were very effective for the DNA photocleavage. Furthermore, the quinoxaline-disaccharide hybrids exhibited selective cytotoxicity against cancer cells with photoirradiation.
本文言語 | English |
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ページ(範囲) | 2777-2779 |
ページ数 | 3 |
ジャーナル | Bioorganic and Medicinal Chemistry Letters |
巻 | 14 |
号 | 11 |
DOI | |
出版ステータス | Published - 2004 6月 7 |
ASJC Scopus subject areas
- 生化学
- 分子医療
- 分子生物学
- 薬科学
- 創薬
- 臨床生化学
- 有機化学