The significant effect of the carbohydrate structures on the DNA photocleavage of the quinoxaline-carbohydrate hybrids

Kazunobu Toshima, Tomohiro Ozawa, Tomonori Kimura, Shuichi Matsumura

研究成果: Article査読

30 被引用数 (Scopus)

抄録

The novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties were designed and synthesized, and their DNA photocleaving abilities were evaluated in order to examine the effect of the disaccharide structures. The configurations of the glycosidic bonds in the disaccharide strongly affected the DNA photocleaving ability, and two β-glycosidic bond linkages were very effective for the DNA photocleavage. Furthermore, the quinoxaline-disaccharide hybrids exhibited selective cytotoxicity against cancer cells with photoirradiation.

本文言語English
ページ(範囲)2777-2779
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
14
11
DOI
出版ステータスPublished - 2004 6 7

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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