The specific opioid κ-agonist U-50,488H inhibits low Km GTPase

Hiroshi Ueda, Hidemi Misawa, Nobuyuki Fukushima, Hiroshi Takagi

研究成果: Article査読

21 被引用数 (Scopus)

抄録

DAGO, a specific opioid μ-agonists stimulated the low Km GTPase activity of membranes of the guinea-pig striatum at 1-1000 nM and this effect was antagonized by naloxone 10-100 nM. On the other hand, U-50,488H, a specific opioid κ-agonist inhibited the low Km GTPase activity of membranes of the guinea-pig cerebellum at 1-100 nM. As this effect was antagonized by MR2266 but not by naloxone, the findings suggest that opioid μ- and κ-receptor stimulation is probably linked to the stimulation and inhibition of low Km GTPase, respectively.

本文言語English
ページ(範囲)129-132
ページ数4
ジャーナルEuropean journal of pharmacology
138
1
DOI
出版ステータスPublished - 1987 6 12
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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