@article{d702a8d3912d469ca76e4c91ae6bd88e,
title = "The Sprouty/Spred family as tumor suppressors: Coming of age",
abstract = "The Ras/Raf/ERK pathway is one of the most frequently dysregulated signaling pathways in various cancers. In some such cancers, Ras and Raf are hotspots for mutations, which cause continuous activation of this pathway. However, in some other cancers, it is known that negative regulators of the Ras/Raf/ERK pathway are responsible for uncontrolled activation. The Sprouty/Spred family is broadly recognized as important negative regulators of the Ras/Raf/ERK pathway, and its expression is downregulated in many malignancies, leading to hyperactivation of the Ras/Raf/ERK pathway. After the discovery of this family, intensive research investigated the mechanism by which it suppresses the Ras/Raf/ERK pathway and its roles in developmental and pathophysiological processes. In this review, we discuss the complicated roles of the Sprouty/Spred family in tumor initiation, promotion, and progression and its future therapeutic potential.",
keywords = "Ras/Raf/ERK, Sprouty/Spred, cancer, oncogene, tumor suppressor",
author = "Tetsuro Kawazoe and Koji Taniguchi",
note = "Funding Information: Foundation for Life Sciences and Arts; Life Science Foundation of Japan; NOVARTIS Foundation (Japan) for the Promotion of Science; Yakult-Bioscience Foundation; Takeda Science Foundation Funding Information: This work is supported by the Japan Society for the Promotion of Science KAKENHI (JP15K21775), the Japan Agency for Medical Research and Development (PRIME; Grant Nos. JP18gm6210008 and JP19gm6210008), the “Kibou Projects” Startup Support for Young Researchers in Immunology, the Astellas Foundation for Research on Metabolic Disorders, the SENSHIN Medical Research Foundation, grants from Bristol-Myers Squibb, the SGH Foundation, the MSD Life Science Foundation, the Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care, the Yasuda Medical Foundation, the Suzuken Memorial Foundation, the Pancreas Research Foundation of Japan, the Waksman Foundation of Japan, the Japanese Foundation for Multidisciplinary Treatment of Cancer, Project Mirai Cancer Research Grants from the Japan Cancer Society, the Okinaka Memorial Institute for Medical Research, the Asahi Glass Foundation, the Foundation for Promotion of Cancer Research, the Kobayashi Foundation for Cancer Research, the Toray Science Foundation, the Vehicle Racing Commemorative Foundation, the JSR-Keio University Medical and Chemical Innovation Center (JKiC), a Research Grant of the Princess Takamatsu Cancer Research Fund, the Tokyo Biomedical Research Foundation, the Daiichi Sankyo Foundation of Life Science, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Medical Research Encouragement Prize of the Japan Medical Association, the Terumo Foundation for Life Sciences and Arts, the Life Science Foundation of Japan, the NOVARTIS Foundation (Japan) for the Promotion of Science, the Yakult-Bioscience Foundation and the Takeda Science Foundation (all to K.T.). Funding Information: Japan Agency for Medical Research and Development, Grant/Award Number: JP18gm6210008 and JP19gm6210008; Japan Society for the Promotion of Science, Grant/Award Number: JP15K21775; “Kibou Projects” Startup Support for Young Researchers in Immunology; Astellas Foundation for Research on Metabolic Disorders; SENSHIN Medical Research Foundation; Bristol-Myers Squibb; SGH Foundation; MSD Life Science Foundation; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Yasuda Medical Foundation; Suzuken Memorial Foundation; Pancreas Research Foundation of Japan; Waksman Foundation of Japan Inc.; Japanese Foundation for Multidisciplinary Treatment of Cancer; Japan Cancer Society; Okinaka Memorial Institute for Medical Research; Asahi Glass Foundation; Foundation for Promotion of Cancer Research; Kobayashi Foundation for Cancer Research; Toray Science Foundation; Vehicle Racing Commemorative Foundation; JSR-Keio University Medical and Chemical Innovation Center (JKiC); Princess Takamatsu Cancer Research Fund; Tokyo Biomedical Research Foundation; Daiichi Sankyo Foundation of Life Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Japan Medical Association; Terumo Funding Information: This work is supported by the Japan Society for the Promotion of Science KAKENHI (JP15K21775), the Japan Agency for Medical Research and Development (PRIME; Grant Nos. JP18gm6210008 and JP19gm6210008), the “Kibou Projects” Startup Support for Young Researchers in Immunology, the Astellas Foundation for Research on Metabolic Disorders, the SENSHIN Medical Research Foundation, grants from Bristol-Myers Squibb, the SGH Foundation, the MSD Life Science Foundation, the Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care, the Yasuda MedicalFoundation,theSuzukenMemorialFoundation,thePancreas Research Foundation of Japan, the Waksman Foundation of Japan, the Japanese Foundation for Multidisciplinary Treatment of Cancer, Project Mirai Cancer Research Grants from the Japan Cancer Society, the Okinaka Memorial Institute for Medical Research, the Asahi Glass Foundation, the Foundation for Promotion of Cancer Research, the Kobayashi Foundation for Cancer Research, the Toray Science Foundation, the Vehicle Racing Commemorative Foundation, the JSR-Keio University Medical and Chemical Innovation Center (JKiC), a Research Grant of the Princess Takamatsu Cancer Research Fund, the Tokyo Biomedical Research Foundation, the Daiichi Sankyo Foundation of Life Science, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Medical Research Encouragement Prize of the Japan Medical Association, the Terumo Foundation for Life Sciences and Arts, the Life Science Foundation of Japan, the NOVARTIS Foundation (Japan) for the Promotion of Science, the Yakult-Bioscience Foundation and the Takeda Science Foundation (all to K.T.). Publisher Copyright: {\textcopyright} 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.",
year = "2019",
month = may,
doi = "10.1111/cas.13999",
language = "English",
volume = "110",
pages = "1525--1535",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "5",
}