The structure of the human thyrotropin β-subunit gene

Tatsumi Keita, Hayashizaki Yoshihide, Hiraoka Yoshiki, Miyai Kiyoshi, Matsubara Kenichi

研究成果: Article査読

32 被引用数 (Scopus)

抄録

We have determined and characterized the entire structure of the human thyrotropin β-subunit (TSHβ) gene. It is 4.5 kb in size and separated into three exons. Primer extension analysis showed one transcription start point, and S1 mapping analysis showed two blocks of polyadenylation sites in normal pituitaries. The same transcripts were observed in TSH-producing adenomas. The 5'-flanking region contains two 'TATA' boxes, two 'CAAT' boxes, and two sequences similar to the cyclic AMP-responsive elements.

本文言語English
ページ(範囲)489-497
ページ数9
ジャーナルGene
73
2
DOI
出版ステータスPublished - 1988 12 20
外部発表はい

ASJC Scopus subject areas

  • Genetics

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