The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

Toshiyuki Nakagawa, Hideyuki Okano, Teiichi Furuichi, Jun Aruga, Katsuhiko Mikoshiba

研究成果: Article査読

206 被引用数 (Scopus)

抄録

Additional subtypes of the inositol 1,4,5-trisphosphate (InsP3) receptor are expressed in a tissue-specific and developmentally specific manner. They differ from the InsP3 receptor structure previously reported in two small variably spliced segments. One segment (SI) is located within the InsP3 binding site, whereas another segment (SII) is located near putative sites for phosphorylation and ATP binding to modulate InsP3 action on Ca2+ flux. Therefore, we speculate that selective use of InsP3 receptor subtypes permits a tissue-specific and developmentally specific expression of functionally distinct channels.

本文言語English
ページ(範囲)6244-6248
ページ数5
ジャーナルProceedings of the National Academy of Sciences of the United States of America
88
14
DOI
出版ステータスPublished - 1991 7 15
外部発表はい

ASJC Scopus subject areas

  • General

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